GNE and neoplasm: Localization (odds ratio (OR), 2.577; 95% confidence interval (CI), 1.246–5.328; p = 0.011), diameter (OR, 2.088; 95% CI, 1.175–3.710; p = 0.012), intravascular tumor thrombi (OR, 5.400; 95% CI, 2.644–11.027; p < 0.001), Lauren’s classification (OR, 3.056; 95% CI, 1.688–5.532; p = 0.001) and GNE expression (OR, 0.262; 95% CI, 0.141–0.487; p < 0.001) were identified as independent risk factors that affect LNM in EGC (Table 3).