CXCL1 and brain ischemia: miR-181c-3p contained in cortical neuron-derived exosomes is found to be an important molecule in the modulation of neuroinflammation after brain ischemia, as it can inhibit the expression of chemokine (C-X-C motif) ligand 1 (CXCL1) and the production of inflammatory factors by astrocytes, which reduces the inflammation burden and achieves the effect of protecting the nerves after ischemic brain injury (IBI).