Furthermore, beta-secretase 2 (BACE2) which cleaves the amyloid precursor protein (APP) in the Aβ domain, preventing Aβ generation, e.g., in Alzheimer’s disease [48], as well as RHOV, CTH, ANK1, HEPHL1, DTX1, DHX9P1, TNFSF11 and AC018738.1 showed strongest evidence of differential expressions in controls (Supplementary Table S4). This evidence concerns the gene ANK1 and Alzheimer disease.