Furthermore, beta-secretase 2 (BACE2) which cleaves the amyloid precursor protein (APP) in the Aβ domain, preventing Aβ generation, e.g., in Alzheimer’s disease [48], as well as RHOV, CTH, ANK1, HEPHL1, DTX1, DHX9P1, TNFSF11 and AC018738.1 showed strongest evidence of differential expressions in controls (Supplementary Table S4). The gene discussed is HEPHL1; the disease is early-onset autosomal dominant Alzheimer disease.