Hashikawa and his team also succeeded in generating a stable strain of rabbits with X-linked severe combined immunodeficiency (X-SCID), harboring a phenotype that encompasses hyperplasia of the thymus and the loss of B and T cells by targeting the Il2rg gene via the CRISPR-Cas9 system [172]. The gene discussed is IL2RG; the disease is T-B+ severe combined immunodeficiency due to gamma chain deficiency.