COL18A1 and endometrial cancer: In the screening of significant E2-inducible lncRNAs in the vicinity of active enhancer cluster regions based on RNA-seq data, we discovered a substantial E2-upregulated transcript derived from a genomic region including a functional ER-binding site (ERBS), which is located in the proximal upstream region of the COL18A1 gene in the antisense direction based on the ENCODE dataset of chromatin immunoprecipitation sequencing (ChIP-seq) in E2-treated endometrial cancer ECC cells retrieved in the UCSC Genome Browser (hg19, chr21:46823868–46824171, GEO accession number: GSM 803422) (Figure 1A).