PI first activates the innate immunity, including the activation of dendritic cells (DCs), macrophages, and natural killer (NK) cells, which release large amounts of proinflammatory/Th1-type cytokines (including IL-12, TNF-α, IFN-γ) [14,15] that promote the infiltration of immune cells (CD45+ leukocytes, including innate immune cells and effector T cells) into the tumor tissues [15]. Here, IFNG is linked to neoplasm.