PGC-1α increases gluconeogenesis and glucose uptake [55,56,57], and although Hepa-c4 cells and tumours have decreased GLUT 1 and GLUT 3, we previously found similar expression of GLUT 2 (the liver-type glucose transporter) in both Hepa-c4 and Hepa-WT cells [18]. Here, PPARGC1A is linked to neoplasm.