MAP1LC3A and lung cancer: We found that wild-type TP53 expression in H2172 reduced the numbers of LC3 puncta and suppressed the conversion of cytosolic LC3 (LC3-I) to the lipidated form of LC3 (LC3-II), as revealed by the LC3 conversion assay with or without the treatment of BafA1, suggesting that TP53 inhibits the early stage of autophagy in lung cancer cells (Figure 5B–D).