MITF and melanoma: MITF has been regarded as one of the most important melanocytic lineage-specific transcriptional factors driving melanocyte differentiation and melanoma development [36], and concurrent qRT-PCR and immunoblotting analysis revealed that either the protein or mRNA levels of MITF was prominently downregulated in the RSL3+ICG001 combined treatment group, compared with a monotreatment group (Figure 4d).