Recently, it has been reported that platinum-tolerant ovarian cancer cells defined by high Wnt receptor Frizzled-7 expression are more sensitive to ferroptosis inducers, and the transcriptional axis Frizzled-7-β-catenin-Tp63-GPX4 pathway is responsible for this influence [25], suggesting the close relationship between Wnt/β-catenin signaling and ferroptosis. The gene discussed is FZD7; the disease is ovarian cancer.