NLRP3 and Hepatic fibrosis: Given that NLRP3 inflammasome-dependent pyroptosis was involved in the liver fibrosis, we used a specific molecular inhibitor of NLRP3 (MCC950) to treat the liver fibrosis mouse model (Figure 2A), aiming to explore whether targeting the NLRP3 inflammasome-dependent pyroptosis can attenuate liver fibrosis progression.