S100A8 and Hepatic fibrosis: The ROC analysis indicated that the circulating GSDMD had the strongest diagnostic value for the occurrence of liver fibrosis with an area under the ROC curve (AUC) of 0.95 (95% CI, 0.9279–0.9842) compared to S100A8, IL-1β or IL-18 with AUCs of 0.93 (95% CI, 0.9011–0.9766), 0.81 (95% CI, 07523–0.8849), and 0.81 (95% CI, 0.7425–0.8803), respectively (Figure 6A).