S100A8 and Hepatic fibrosis: Furthermore, circulating GSDMD had the highest diagnostic value for identifying severe liver fibrosis, which yielded an AUC of 0.91 (95% CI, 0.8614–0.9725) compared to IL-1β, S100A8, and IL-18 with AUCs of 0.90 (95% CI, 0.8523–0.9677), 0.89 (95% CI, 0.8209–0.9606), and 0.89 (95% CI, 0.8348–0.9591), respectively (Figure 6B).