Under hypoxia, HIF-1α upregulation inhibits ferroptosis by preventing BMMs autophagosome formation and promotes the expression of RANKL in osteoblasts by activating Janus kinase 2 (JAK2)/Signal Transducers and Activators of Transcription 3 (STAT3) pathway, which supports BMMs differentiating into osteoclasts, leading to osteoporosis [16,21,23,24]. Here, JAK2 is linked to osteoporosis.