In addition, miR-210 significantly promotes HIF-1α and VEGF expression in BMSCs dose-and-time-dependently, upregulates alkaline phosphatase (ALP) and Osterix, inhibits peroxisome proliferators-activated receptors (PPARγ), and induces BMSCs differentiating into osteoblasts, improving osteoporosis caused by estrogen deficiency [156]. The gene discussed is HIF1A; the disease is osteoporosis.