In addition, matrix metalloproteinase-2 inhibitor 1 (MMP2-I1) could induce BMSCs osteogenesis differentiation and promote Type H vessel angiogenesis through the HIF-1α signal pathway, rescuing osteonecrosis, bone defect, as well as osteoporosis [158,159] (Figure 4). This evidence concerns the gene HIF1A and osteonecrosis.