SPARC and intervertebral disk degenerative disorder: Previous studies have revealed that exercise alleviates LBP in a secreted protein, acidic, rich in cysteine (SPARC)-null mouse model associated with disc degeneration by reducing global DNA methylation and the mRNA expression of epigenetic relevant regulatory genes such as DNA methyltransferase (DNMT), Methyl-CpG Binding Domain Proteins, and Ten–eleven Translocation (Tet) Family [9].