SPECC1 and Parkinson disease: Moreover, circSLC8A1 has been linked to oxidative stress-related Parkinsonism [59], whereas circSPECC1, transcribed from Sperm Antigen with Calponin Homology and Coiled-Coil Domains 1 (SPECC1) is modulated upon H2O2 stimulation in hepatocellular carcinoma [60].