Moreover, the study also showed marked increases in p53, p21, and p16 expression in the endothelium of sedentary older adults (mean 60 years) and younger sedentary individuals (mean 22 years), but similar senescence-related changes in p53 and p21 protein expression in vascular ECs were not observed in older adults (mean 59 years) with habitual exercise; these data suggest that aerobic exercise might suppress endothelial senescence and be considered as a potential intervention to prevent endothelial dysfunction during aging [76]. This evidence concerns the gene CDKN2A and endothelial dysfunction.