CDKN2A and endothelial dysfunction: The authors found that the expression of p53 (a cellular senescence transcription factor) and the cell cycle protein-dependent kinase inhibitors p21 and p16 in vascular ECs were negatively correlated with endothelial function (brachial artery flow-mediated dilatation), suggesting that endothelial senescence is associated with endothelial dysfunction development [76].