The general proteomic profiling showed α-synuclein to be of higher abundance in NMGs of DLB cases, which we were able to verify in targeted PRM-experiments, while stress granule marker proteins as well as those for dopaminergic neurons were decreased, with the latter being again in line with the regularly reported selective loss of dopaminergic neurons in the SN. This evidence concerns the gene SNCA and Lewy body dementia.