Our studies revealed that activation of Akt2 signaling in the RPE triggers neutrophil infiltration in human AMD patients and in our mouse model, and that this infiltration is associated with retinal degeneration [17], a finding confirmed by the fact that inhibition of Akt2 in the mouse model reduced neutrophil infiltration and alleviated early RPE changes [17]. The gene discussed is AKT2; the disease is age-related macular degeneration.