In addition, we have shown that RPE cells trigger neutrophil activation and infiltration into the retina [17] of a mouse model of dry AMD which lacks the Cryba1 gene (encodes βA3/A1-crystallin) specifically in the RPE (conditional knockout; cKO) [19,20] and in human dry AMD patients [16,17]. Here, CRYBA1 is linked to dry age related macular degeneration.