In addition to adhesion and transmigration due to elevated expression of cell surface integrins, activated neutrophils express high levels of lipocalin-2 (LCN-2), myeloperoxidase (MPO), and activated neutrophil extracellular traps (NETs), which have been shown to be critical in AMD pathogenesis [17]. The gene discussed is MPO; the disease is age-related macular degeneration.