DPP4 and obesity due to melanocortin 4 receptor deficiency: In agreement with our findings, we have previously reported that in vivo ABD AT pO2 was positively associated with the AT gene expression of several proinflammatory markers [22] and that low physiological pO2 exposure reduced the gene expression of IL-6 and DPP-4 in adipocytes derived from women with obesity [16].