TNF and obesity due to melanocortin 4 receptor deficiency: Low physiological pO2 levels did not significantly alter the gene expression of PAI-1, TNFα, or MCP-1 in differentiated ABD and FEM hMADS derived from NW and OB individuals (Figure 1D–G), except for a modest but significant (p = 0.041) increase in adiponectin gene expression in FEM differentiated hMADS derived from individuals with obesity (Figure 1E).