Moreover, in the advanced setting of pluri-treated HNSCC patients, we demonstrated among a panel of 17 cytokines, that high IL-2, low IL-8, and CCL-2 correlated with OS, and that increases in IL-10, IL-8, and CCL4 correlated with poor outcomes (14). Here, CXCL8 is linked to head and neck squamous cell carcinoma.