Pries et al. [17] classified HNSCC-relevant cytokines based on their action: angiogenesis (FGF, IL-8, HGF, VEGF, PDGF) and immune suppression (PGE2, TGF-β, IL-10, IL-4, GM-CSF). This evidence concerns the gene CXCL8 and head and neck squamous cell carcinoma.