Considering the findings regarding the association of PTPN22 and IL10 gene expression with disease activity and with the presence of renal involvement in SLE patients by plotting these data into a 3D plot, we were able to confirm that most of the SLE patients who presented renal manifestations had the lowest levels of PTPN22 and IL10 mRNA as well as the highest Mex-SLEDAI scores (Figure 2D). Here, PTPN22 is linked to systemic lupus erythematosus.