MUC16 and endometrial cancer: HE4 and CA125 were less accurate for the detection of endometrial cancer in pre-menopausal compared with postmenopausal women [HE4: AUC 0.75 (95% CI: 0.65–0.84) vs. 0.78 (95% CI: 0.74–0.81), CA125: AUC 0.67 (95% CI: 0.56–0.77) vs. 0.72 (95% CI: 0.68–0.76)] (Figure S2).