MUC16 and metastatic malignant neoplasm in the lymph nodes: It is known that MI ≥ 50%, LVSI and grade are associated with risk of lymph node metastasis [46], and whilst we were not able to assess the value of HE4 and CA125 in detection of lymph node metastasis due to small numbers of women undergoing lymphadenectomy at our unit, we have shown the utility of HE4 and CA125 to detect these associated high-risk features, which may indicate lymphadenectomy may be appropriate in those with a raised HE4.