No studies have evaluated the serum markers in combination with endometrial thickness for endometrial cancer detection; however, urine CA125 and HE4 in combination with ET has been investigated, with a reported improvement in AUC with the addition of urine CA125 to ET compared with ET alone (AUC 0.97 vs. 0.94, respectively) [33]. The gene discussed is MUC16; the disease is endometrial cancer.