On the other hand, the VWF/ADAMTS13 imbalance, with elevated levels of VWF and decreased ADAMTS13 activity [13,16] and complement-induced coagulopathy [17] recalls the characteristics of thrombotic microangiopathy and, beyond macrovascular thrombosis, microvascular thrombosis is a prominent feature in the pathophysiology of both lung and multi-organ complications triggered by SARS-CoV-2 infection [17,18]. The gene discussed is VWF; the disease is Genetic thrombotic microangiopathy.