Interestingly, it was reported that METTL3 mRNA and protein expression was increased in acute myeloid leukemia (AML) cells compared to healthy hematopoietic stem and progenitor cells [106], and a higher expression was reported in pediatric ALL ETV6/RUNX1-positive patients when compared to controls [107]. This evidence concerns the gene RUNX1 and acute myeloid leukemia.