CD274 and lung cancer: IL-6/IL-8/VEGFA: The production of the triad (IL-6, IL-8, and VEGF) is reportedly induced through STAT1 signalling in lung cancer [41]; hence, the simultaneous increase in IL-6/IL-8/VEGFA and CXCL9/OSM/PD-L1 in our study could propose the possible involvement of the JAK/STAT signalling pathway as a core regulator of hyperinflammation in COVID-19 patients.