CD40LG and COVID-19: Furthermore, platelets are hyperresponsive, more adhesive, and stimulated to release inflammatory cytokines leading to thrombo-inflammation in COVID-19 [36]; as a consequence, soluble CD40 Ligand, as a plasmatic marker for platelet aggregation, was reported to be enhanced in deceased patients compared to recovered COVID-19 patients [36], suggesting CD40 as a prognostic marker for thrombo-inflammation in severe COVID-19 cases.