Interestingly, OSM also binds to the OSM receptor, leading to the recruitment of JAKs and subsequent signal transduction and activation of STAT3 [40]; thus, we can hypothesize that both CXCL9 and OSM participate in the upregulation of PD-L1 through the STAT activation pathway in COVID-19 patients (Figure 1). This evidence concerns the gene STAT3 and COVID-19.