It has been shown that in severe COVID-19 patients, T lymphocytes are switching from hyperactivated status to exhaustion, expressing higher levels of PD-L1; however, the data on the importance of PD-L1 dysregulation during SARS-CoV-2 infection are yet inconclusive and our knowledge is currently limited on the role of soluble PD-L1 in COVID-19 based on the different grades of severity and prognosis [37]. The gene discussed is CD274; the disease is COVID-19.