GNAS and adenoma: One retrospective study from TAIPAI registry (a 2022 paper) showed that 36.7% of patients with PA and ACS (n = 98) had mutations which are related to cortisol producing adenomas (PRKACA and GNAS), and this subgroup of Connshing syndrome associates a higher value of cortisol after a 1 mg DXM inhibition test (5.6 μg/dL) when compared to the subgroup without these mutations (2.6 μg/dL, p = 0.003), as well as a larger diameter (2.22.2 ± 0.3 versus 1.9 ± 0.7 cm, p = 0.025).