A Chinese study of 555 PA patients identified 22 of them with Connshing syndrome, a group that showed a larger tumour diameter than the pure PA group (p < 0.05), but also had a higher ratio of cardiovascular complications and different types of glucose profile anomalies, as well as osteopenia and osteoporosis (p < 0.001), whilst 17/22 individuals harboured KCNJ5 mutations [64]. This evidence concerns the gene KCNJ5 and neoplasm.