CYP11B1 and adrenal gland neoplasm: For an example of such a situation which does not fit into the Connshing group, we mention one case report published by the CONPASS group in 2020 of a 54-year-old male who was admitted for PA and subclinical Cushing syndrome, and presented synchronous detection of bilateral adrenal tumours: a right adrenal adenoma with positive CYP11B2 immunostaining (aldosteronoma) underlying a somatic KCNJ5 mutation (Leu168Arg), and a left adrenal tumour with positive immunostaining for CYP11B1 (negative for KCNJ5), responsible for persistent hypercortisolism [31].