Based on guideline level, individuals can be diagnosed with MEN1 if they develop two of the three main MEN1-related tumors (pituitary, parathyroid, and pancreatic neuroendocrine tumors); if they present with one MEN1-associated tumor and are a first-degree relative of a patient diagnosed with MEN1; or if, despite being asymptomatic, a mutation of the MEN1 gene is confirmed [1]. This evidence concerns the gene MEN1 and pancreatic neuroendocrine tumor.