To study the role of LCN2 in NPC progression, we analyzed the dataset (GSE12452) from the Gene Expression Omnibus (GEO) database and found that the expression levels of LCN2 were significantly decreased in the tumor group (n = 31) compared with the normal group (n = 10) (Figure 1A). Here, LCN2 is linked to nasopharyngeal carcinoma.