UGT2B4 and Familial prostate cancer: For example, the prostate cancer DU145 cell line had two mutations in UGT1A10 [c.13G > T (Gly5Trp); c.13_14delinsTT (Gly5Val)] and one mutation in four other UGT genes, including UGT2B4 [c.1372G > T (Asp458Tyr)], UGT2B15 [c.728G > C (Arg243Thr)], UGT2B17 [c.32T > A (Leu11Gln)] and UGT2B28 [c.1262C > A (Ser421Ter)].