ERBB2 and rectal cancer: For instance, Chen et al. demonstrated that ACY1 regulated the proliferation, migration, and invasion of human neuroblastoma cells via the extracellular signal-regulated protein kinase 1/2 and transforming growth factor-β1 signaling pathways [44], and Xu et al. [45] revealed that targeting the ACY1 gene might regulate HER2 and TRAIL expression levels and reduce the occurrence and inhibit the development of rectal cancer.