Taken together, Hsp70, which is increased in the circulation of NSCLC patients with advanced-stage tumors acts, as a danger signal for NK cell stimulation, and patients with advanced UICC stages exhibit an increased prevalence of NK cells that resemble the phenotype of NK cells after ex vivo stimulation with the Hsp70 peptide TKD and IL-2. This evidence concerns the gene IL2 and non-small cell lung carcinoma.