The progressive decrease in CD4+ T helper cells with raising UICC stages, which might lower the IL-2 concentrations in the circulation, might also explain the insufficient tumor control by CD8+ T cells and the ineffectiveness of NK cells to kill membrane Hsp70-positive tumor cells, despite the presence of the danger signal Hsp70 in the circulation of patients with advanced UICC stages. The gene discussed is CD8A; the disease is neoplasm.