In AITL, TET2 mutations are associated with advanced-stage disease [18,22], thrombocytopenia [18], high International Prognostic Index (IPI) scores [18,28], an increased number of involved extranodal sites [18], the presence of B symptoms [22], and elevated lactate dehydrogenase (LDH) levels [22]. This evidence concerns the gene TET2 and angioimmunoblastic T-cell lymphoma.