IDH2 and neoplasm: These mutations have been found not only in tumor cells from patients with T-cell lymphoma [3,4,5,8,30,48,50] but also in multiple lineages of normal bone marrow and blood cells [3,4,7,51,52], including B cells, myeloid cells, and myeloid progenitor cells [7,8], whereas RHOA and IDH2 mutations are confined only to tumor cells [7,8].