TET2 and angioimmunoblastic T-cell lymphoma: Notably, TET2 mutation and RHOA G17V have a synergistic effect on human AITL pathogenesis, with co-mutations of TET2 and RHOA observed in 60–70% of AITL cases [6,7,36], leading to AITL-like disease with high penetrance [41,43,44].