nTFHL-F and AITL have very similar genetic profiles with mutations in TET2, DNMT3A, and IDH2, as well as the small GTPase RHOA [14,15]; however, nTFHL-F has specific genetic alterations due to the translocation t (5;9) (q32; q22) leading to ITK-SYK fusion, which is rarely seen in AITL [16,17]. This evidence concerns the gene DNMT3A and angioimmunoblastic T-cell lymphoma.