RAD51 and cancer: Importantly, the genomic instability caused by three different drugs (camptothecin [33], a topoisomerase inhibitor; 5-fluorouracil, a thymidylate synthase inhibitor; and paclitaxel, an antimicrotubule agent), which induce DNA breaks by different mechanisms, was minimized by addition of RAD51 inhibitor in cell lines representing three different cancers (EAC, colon and breast).