Recently, Singh et al. have reported a series of six cHL/DLBCL and DLBCL/cHL sequential lymphomas, and identified identical variants in both contingents (including TNFAIP3, XPO1, TP53, and B2M), reinforcing the clonal relationship between these lymphomas and the concept of plasticity occurring within mature B-cells [143]. Here, B2M is linked to diffuse large B-cell lymphoma.