The cutoff value for DpR of 60% seemed reasonable given that cutoff values of 50% or 62.4% were previously adopted as predictors of longer survival for first-line chemotherapy in Japanese patients with HER2-positive gastric cancer, for whom the median DpR was 56.8% [19], and in patients with colorectal cancer [20], respectively. This evidence concerns the gene ERBB2 and colorectal cancer.