Once paired, the tyrosine residues on the receptor’s intracellular domains are mutually phosphorylated, leading to the initiation of signaling pathways, including the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway, and, consequently, tumor cell proliferation, angiogenesis, invasion and metastasis [49,50,51,52]. The gene discussed is AKT1; the disease is neoplasm.