Because the application of ICIs aims to inhibit the interaction of PD-1 with PD-L1 and increase T cell survival and proliferation, consequently leading to an enhanced tumor-directed immune response, it has been suggested that combining ICIs with anti-Her-2/neu mAbs, such as Trastuzumab, could act in a synergistic manner to delay or even prevent resistance to the mAb [68]. This evidence concerns the gene CD274 and neoplasm.