Eosinophils mediate anti-tumor responses via direct and indirect mechanisms, e.g., by secreting tumor cytotoxic proteins, such as major basic protein (MBP), ECP, eosinophil-derived neurotoxin (EDN) and granzymes, as well as by limiting tumor cell migration through secretion of interleukin (IL)-12 and IL-10. This evidence concerns the gene RNASE3 and neoplasm.