In addition, survival analyses for OS of the 45 metastatic melanoma patients were evaluated using peripheral-blood AEC (Supplementary Figure S9a,b), ECP (Supplementary Figure S9c,d) and EPX (Supplementary Figure S9e,f) serum levels at BE and C4, as shown in Supplementary Figure S9a–f. This evidence concerns the gene RNASE3 and metastatic melanoma.