Multivariate analysis on 3726 early stage breast cancers highlighted that bone is the most common metastatic site in all subtypes except basal-like tumors, that luminal/HER2 and HER2-enriched tumors are associated with a significantly higher rate of brain, liver, and lung metastases, that basal-like tumors have a higher rate of brain, lung, and distant nodal metastases, but a significantly lower rate of liver and bone metastases, and that triple-negative non-basal tumors demonstrate a similar pattern, but are not associated with fewer liver metastases [35]. This evidence concerns the gene ERBB2 and breast carcinoma.