Recently, in breast cancer models, it was observed that while loss of the epithelial marker E-cadherin increases invasion and dissemination in vitro, cells with E-cadherin loss generate significantly less lung metastases in vivo, and E-cadherin promotes the metastasis of invasive ductal breast carcinoma by enhancing the survival of tumor cells [147]. The gene discussed is CDH1; the disease is breast carcinoma.