In the glioma samples, compared with the control samples, the expression levels of ACSL1, GCAT, SEMA3G, and WNT7B were increased, while those of BMP2, EN1, GRNDE, KLF10, PLOD3, SFRP2, TFPI, and TPX2 decreased. The gene discussed is SFRP2; the disease is central nervous system cancer.