In addition, CD73 levels were positively related to tumor mutation burden (TMB) in BRCA, COAD, ESCA, GBM, OV, PAAD, SARC, SKCM, THYM, and UCEC, and negatively linked to TMB in BLCA, CESC, HNSC, LUAD, PCPG, PRAD and READ (Figure 3C; p < 0.05). The gene discussed is NT5E; the disease is neoplasm.