IGF1R and acute lymphoblastic leukemia: Apart from DCs, myeloid cells, including macrophages, monocytes, and granulocytes, also support T-ALL survival and progression, both in vitro and in vivo; notably, some myeloid cells sensitize T-ALL cells to the IGF1R signaling, indicating that myeloid cells promote T-ALL progression at least in part by activating IGF1R signaling [95] (Figure 2B).