Additionally, co-expression of Tal1 with LIM domain only 1 (Lmo1) or Lmo2 not only accelerates T-ALL onset and progression [9,10] but also provides a favorable context for the acquisition of activating mutations of notch receptor 1 (NOTCH1) and the emergence of T-LICs [11]. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.