T-LICs were mostly studied in genetically engineered mouse models of T-ALL, among which, the T-cell acute lymphocytic 1 (TAL) basic helix-loop-helix (bHLH) transcription factor 1 (Tal1)-induced mouse model stands out, since 28% of the Tal1 transgenic mice develop leukemia [8]. Here, TAL1 is linked to acute lymphoblastic leukemia.