Moreover, the retroviral or transgenic mouse models of Notch1-induced T-ALL [13,14,15,16,17], KRAS proto-oncogene (Kras)G12D-induced T-ALL [13,18], and phosphatase and tensin homolog (Pten)-null T-ALL [19,20] are also used for identification of T-LICs in terms of different T-ALL-causing mutations. The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.