Recently, a biomarker analysis from the Checkmate 214 trial revealed that putative biomarkers previously reported to benefit from immune checkpoint inhibitor-containing regimens in mRCC, including PD-L1 expression on tumor cells and tumor mutation burden, were not predictive for survival in patients with mRCC treated with ipilimumab plus nivolumab, whereas their transcriptome analysis showed an association between inflammatory response and progression-free survival with nivolumab plus ipilimumab [6]. This evidence concerns the gene CD274 and neoplasm.