In vitro, NK-92/9.28.z cells exhibited specific cytotoxicity against GPC3+ HCC cells with high levels of secretion of IFN-γ, and the function of NK-92/9.28.z cells was not affected by inhibitory factors, such as hypoxic, soluble TGF-β and GPC3 [148]. Here, GPC3 is linked to hepatocellular carcinoma.