Indeed, in BC cell lines, in which overall HER2 mRNA was found to reflect tumor addiction to HER2, pHER2 levels, activation of HER downstream signals (mainly AKT) and response to anti-HER2 drugs, we found an increase in HER2 transcription in cells grown in the absence of estrogens or in which ER degradation is induced by fulvestrant. Here, ESR1 is linked to neoplasm.