The goal of this retrospective study was to evaluate the potential prognostic value of the Cell Division Cycle Associated 5 (CDCA5), which is a member of the cyclin dependent kinase family and plays an important role in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signaling pathway involving in cell division, cancer cell migration, and apoptosis. This evidence concerns the gene CDCA5 and cancer.