Furthermore, our results showed that the survival probabilities of clinical patients have a positive correlation with SOX4 expression, in which overexpressing SOX4 inhibited NB cell proliferation; elongated cells’ neurites; and blocked the cell cycle in the G1 phase and that knockdown of the expression of SOX4 partially reversed the function of ATRA in NB cell proliferation, cells’ neurites, and the cell cycle. This evidence concerns the gene SOX4 and neuroblastoma.