Yuyin Yi et al.’s study found that SOX4 promotes the BMP2regulated differentiation of invasive trophoblast [46], while Wei Han et al.’s study found that FHL3 blocked glioma cell proliferation via the downregulation of SOX4 [47], and Dong Chen et al.’s study shows that the knockdown of SOX4 decreased cell proliferation, migration, and invasion and induced apoptosis in osteosarcoma cell lines [48]. The gene discussed is FHL3; the disease is osteosarcoma.