Of note, a novel PARPi, AMXI-5001, has been shown to stimulate the expression of poliovirus receptor (PVR, CD155, necl-5) [163], an adhesion molecule belonging to the nectin/nectin-like family, often overexpressed on tumor cells and involved in many different processes such as cell adhesion, migration, and proliferation [164]. Here, PVR is linked to neoplasm.