Conversely, according to other studies [100], PARP inhibition has been shown to induce cytosolic DNA accumulation and type I IFN response, along with increased intra-tumor CD8+T cell infiltration dependent on C-C chemokine ligand 5 (CCL5) and CXCL10 chemokines, irrespective of the BRCA mutational state. Here, PARP1 is linked to neoplasm.