Of note, inhibition of PARP-1 has been shown to promote NKG2D ligands expression on LSCs, without affecting their expression on non-stem tumor or normal hematopoietic cells in a preclinical AML mouse model [158], providing a rationale to combine PARPi and NK cell-based immunotherapy for AML treatment [143]. Here, PARP1 is linked to acute myeloid leukemia.