In fact, in addition to favoring tumor infiltration of CD8+ T lymphocytes [87], the activation of the CCL5/CC type 5 chemokine receptor (CCR5) axis is involved in the development and progression of several malignancies, including breast and ovarian cancer, and in the generation of an immunosuppressive TME [125,126,127,128]. Here, CCL5 is linked to neoplasm.