IRF3 and neoplasm: STING also stimulates the activation of NF-κB, which collaborates with IRF3 in promoting the release of pro-inflammatory cytokines such as IL-1β, IL-6 and IFN-γ [84,85,86] Furthermore, although type I IFNs are mainly produced by DCs in the TME, a paracrine cGAS/STING pathway stimulation has been observed in neighboring DCs, exclusively in BRCA1-deficient models of TNBC and ovarian cancer, mediated by pro-inflammatory cytokines release and possibly tumor DNA exocytosis [87,88], according to the described role played by extracellular DNA in the generation of an inflammatory phenotype [89].