On the other hand, additional interference of PARPi with ICs-mediated signaling has been also demonstrated in preclinical mouse models of BRCA1-deficient ovarian tumors showing reduced expression of PD-1, Lymphocyte-activation gene 3 (LAG-3), and T-cell immunoglobulin (TIM-3), after combined PARPi and PD-1 blockade, resulting in reactivation of T cell functionality [98,121,122,123]. This evidence concerns the gene PDCD1 and ovarian neoplasm.