TNFSF10 and neoplasm: However, the binding of TRAIL or its agonists on death receptors has also been linked to non-apoptotic signaling pathways induction, such as NF-κB [8], JNK [9], p38 [10], MAPK superfamily [11,12,13], Src, Rac1 [6], and Akt [14]; therefore, stimulating the tumor cell survival, proliferation and/or migration.