TRAIL, by binding to DR4 and DR5, is able to induce apoptosis of tumor cells by recruiting the intracellular death domains of Fas-associated with death domain (FADD) protein, therefore activating the recruitment and cleavage of the pro-caspase-8 in a complex called a death-inducing signaling complex (DISC). Here, TNFRSF10B is linked to neoplasm.