TNFRSF10B and bone neoplasm: We, here, provided important insights into: (1) the role played by the non-apoptotic pathways induced by TRAIL in the resistance of this model to the DR5-agonist AMG655; (2) the validation of TRAIL-based therapies in pediatric bone tumors; and (3) the proof of concept for new adjuvant targets that can synergize with TRAIL receptors agonists.