Therefore, the current study aims to unravel the molecular mechanisms that underscore the anti-proliferative effects of GS in MM cells and, most importantly, to explore the effect of GS alone or in combination with bortezomib (BTZ), on regulating the JAK/STAT signaling pathway and association of this pathway with the expression of HMGB1. This evidence concerns the gene HMGB1 and Miyoshi myopathy.