Interestingly, the splice site variant in BRCA1 gene (ENST00000471181.2: c.4357+1G>A) was identified in three related cases, all had a family history of colon, stomach, thyroid and pancreatic cancer without the presence of breast or ovarian cancer in the family (Supplementary Figure S1). This evidence concerns the gene BRCA1 and pancreatic neoplasm.