The top five enriched molecular functions in SCLC-M and SCLC-I tumors are shown in Figure 3A. As expected, genes associated with the EMT, angiogenesis, and TGFβ signaling pathways were relatively up-regulated in SCLC-M tumor epithelial cells compared with SCLC-I tumor epithelial cells. This evidence concerns the gene TGFB1 and small cell lung carcinoma.