Taken together, we annotated the six NMF SCLC tumors (NMF1 to NMF6) as SCLC-M (NMF1; mesenchymal, elevated YAP1 activity and EMT scores), SCLC-I (NMF2; inflamed, elevated immune scores), SCLC-A/-P/-N (NMF3–5; elevated activities of ASCL1, POU2F3, and NEUROD1, respectively), and SCLC-H (NMF6; elevated tumor hypoxia scores). Here, YAP1 is linked to neoplasm.