YAP1 and head and neck squamous cell carcinoma: In HPV-related HNSCC, HPV oncoproteins E6 and E7 also activate YAP nuclear localization, promote YAP, TAZ, and TEAD as well as their transcriptional targets, and inhibit upstream YAP1 inhibitors (e.g., PTPN14, MST 1/2) [133,134].